Nitric oxide and oxygen radicals: a question of balance
نویسندگان
چکیده
منابع مشابه
Oxygen radicals, nitric oxide and human inflammatory joint disease.
Interest in the role of free radicals in rheumatoid arthritis (RA) stems from the seminal work of McCord,' who noted the decreased viscosity of synovial fluid in RA patients and showed that a similar decrease could be produced by exposing synovial fluid, or solutions of hyaluronic acid, to a system generating superoxide radical, 02-. McCord's observations led to interest in the use of intraarti...
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Oxygen (O(2)) at high pressures acts as a neurotoxic agent leading to convulsions. The mechanism of this neurotoxicity is not known; however, oxygen free radicals and nitric oxide (NO) have been suggested as contributors. This study was designed to follow the formation of oxygen free radicals and NO in the rat brain under hyperbaric oxygen (HBO) conditions using in vivo microdialysis. Male Spra...
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The reduced biological effects of radiation exposure seen in cells after conditioning exposures to a low dose or at a low-dose rate (i.e., the acquisition of resistance against high-dose radiation) is called the "radioadaptive response" and many studies concerning this phenomenon have been reported since the 1980s. Radioadaptive responses have been observed using various end points, such as chr...
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Osteoarthritis and rheumatoid arthritis are characterized by focal loss of cartilage due to an up-regulation of catabolic pathways, induced mainly by pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumour necrosis factor alpha (TNFalpha). Since reactive oxygen species are also involved in this extracellular-matrix-degrading activity, we aimed to compare the chondrocyte oxidative st...
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Oxidative stress is a key process involved in the action of several therapeutic modalities used in cancer treatment. Ischemia reperfusion insult provides a model system for investigating the processes involved in determining the sensitivity of tumor tissue to oxidative stress. We have investigated the response of the murine CaNT tumor to ischemia reperfusion injury and the role that oxygen radi...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1995
ISSN: 0014-5793
DOI: 10.1016/0014-5793(95)00764-z